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2005 Scientific Strategic Plan

The Enterprise's Scientific Strategic Plan for accelerating HIV vaccine research was published in the February 2005 issue of Public Library of Science (PLoS) — Medicine. The plan described the major challenges facing the field and made recommendations in six priority areas:

1
Vaccine Discovery

The immediate goal is to design candidate vaccines that cause the immune system to produce protective responses from both of its major arms — cellular immunity and neutralizing antibodies.

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2
Laboratory Standardization

The laboratory assays that researchers use to assess immune response may not be comparable, severely hampering decisions about which candidates to pursue for further testing.

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3
Product Development and Manufacturing

Once researchers have identified a vaccine design that they believe is promising, a critical phase of vaccine research is developing a manufacturing process that yields consistent batches over time.

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4
Clinical Trials Capacity

Three phases of clinical trials in humans are required to fully test a vaccine candidate.

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5
Regulatory Issues

National regulatory oversight of clinical trials is the cornerstone of safe and scientifically valid medical research.

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6
Intellectual Property Issues

Researchers routinely seek patents and other intellectual property protections for their inventions.

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