The search for a safe and effective HIV vaccine has progressed further and faster in the last few years than at any time since the epidemic began. This progress poses new questions, new opportunities and new challenges as to what and how the HIV vaccine research endeavor should move forward.
In 2012, the Enterprise launched Timely Topics in HIV Vaccines, a strategy series convening experts as rapidly as possible to analyze, address, and respond to unresolved and emerging priority issues in the field. Through an open call for proposals, the Enterprise is working to identify the most important strategic needs of the field and sponsoring think tanks, meetings, forums and other events to tackle these issues.
We will carefully review all ideas, and are particularly interested in topics that:
- help keep the field broad, open, and cutting edge, which includes building on lessons from early HIV infection and pathogenesis, other HIV prevention research, new technologies, or vaccines against other diseases;
- by defining protective mechanisms in a variety of models, help refine criteria for vaccine design and optimization, in hopes of informing decision-making and improving the chances of success in efficacy trials;
- lead to better incorporation and emphasis on development pathways, enabling better selection of candidates, more effective longer-term planning and preparation, and smoother transition between development phases.
Tell us what priority issues/opportunities you believe will facilitate HIV vaccine research and development. Individuals, groups and organizations are invited to submit ideas/topics at any time, submitted ideas will be reviewed on a rolling basis. If selected, we will work with you to develop and implement a plan to convene and address the proposed issue/opportunity and will provide full or partial support for the convening depending on the opportunity.
Learn more about the process to submit and evaluate topics here.
How Complement Stimulates B-cell Responses
Passive Immunization Trials and Vaccine Design
Can passive immunizations with bNAbs set goal posts for an HIV vaccine?
Adjuvants and Formulation of HIV-1 Env Vaccines
Meeting to review criteria for andjuvant selection and assays to monitor protein stability
Capturing Participants Info for Mucosal Sampling
Investigators' guide to help capture participant information that impact mucosal responses
Bench to Clinic Tool
Web-based tool to guide in taking candidates from concept to Phase I trials
Think tank on inducing durable antibody responses through HIV vaccination
A consultation to help determine the intersection between therapeutic and preventive vaccines
Vaccine-Induced Sero-Reactivity (VISR)
A meeting to review current efforts and gaps in addressing VISR
HIV Prevention Trials in Infants
A consultation to discuss challenges of conducting trials in HIV-exposed infants
Strengthening policies to broaden access to HIV vaccine research