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HIV VACCINE ELECTRONIC (E) RESOURCE
ID#:21247BR    Posted: 6 May 2011
Research Associate
Type of Position: Full-time   
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Deadline: 1 Jan 2038
Emory Vaccine Center at Yerkes
The Emory Vaccine Center represents one of the largest academic vaccine centers in the world, and is renowned for its expertise in cellular immunity and immune memory. This expertise leads to the creation of new technologies for the prevention of emerging infectious diseases. Established in 1996 with support from Emory University and the Georgia Research Alliance, the Emory Vaccine Center has including 26 regular faculty, 9 affiliate faculty, over 100 post doctoral fellows and graduate students, plus laboratory, clinical, and administrative staff.
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DETAILS

A position in bioinformatics/ systems biology with a focus on Microarray Analysis is available in the laboratory of Dr. Bali Pulendran at the Emory Vaccine Center at Yerkes in Atlanta, Georiga USA. The successful applicant will join a dynamic, interdisciplinary group of researchers including immunologists, vaccinologists, clinicians, bioengineers and bioinformaticians. 

RESPONSIBILITIES:

The successful applicant will work in a multi-disciplinary team to use microarray and systems biology approaches to explore the induction and regulation of immune responses in humans, non human primates and mice to pathogens, vaccines, and adjuvants. The primary goals of this effort are to: (i) identify key, early correlates of vaccination or ‘molecular signatures’ that defines the development of protective immune responses, (e.g. Nature Immunology vol 10, 1, p116-125, 2009); (ii) identify early signatures of disease progression in infectious diseases, and (iii) exploit the knowledge gained from (i) and (ii) in the design of novel adjuvants and vaccines. 

The position will involve leading the analysis of and the development of analysis protocols for large in-house gene-expression datasets,

Correlation of these analyses with immunological studies (including multiplex cytokine analysis, flow cytometry studies, antibody titers, metabolomics, etc.). 

Correlation with informatics studies (including protein-protein and protein-DNA interaction network information from public and our manually-curated, in-house developed database) will also be performed. 

The position will require the applicant to be at the forefront of informatics analysis, hands-on evaluation, adaption and incorporation of new informatics methods (eg DAMIP), and a leader in design and development of new analytical algorithms.

Maintain a database / archive for the curation and accessibility of the raw files, normalized files and meta-analyses, collaborative “sharing” of experimental data and results.

Additional responsibilities include being a team leader. Confident to collaborate with a multi-disciplanary team and to coordinate with the statisticians.

ELIGIBILITY

REQUIREMENTS:

The qualified applicant will have a Masters Degree or a Ph.D. (or is currently working toward the degree) in bioinformatics, a relevant biological discipline, or in computer science plus demonstrated experience in bioinformatics research. Previous demonstrated experience with large-scale Microarray Analyses, or with genomic network analyses, would be strongly desirable. A clear understanding of the latest in gene expression technologies and the challenges associated with microarray and meta-analyses. Solid understanding of fundamental systems biology concepts. 

Familiarity with working in a Linux/Unix environment, plus experience with relational databases (e.g. MySQL, Oracle) and fluency in at least one programming language (Perl, Java, Python, C or C++) are required.

PREFERENCES: 

Research-oriented curiosity to seek out and develop novel tools, and create a “new way of looking at things.” In-depth knowledge of online / open source bioinformatics tools, databases, and pathway analysis. Wide-understanding of commercially available and open source bioinformatics tools. Strong quantitative or statistical background would be a plus.

Excellent attention to detail and analytical skills. Excellent organizational skills. Ability to work independently. 

Applicant must have the ability to work in a fast moving interdisciplinary team environment, as well as the ability to discuss issues and provide solutions to scientists with different backgrounds. Excellence in verbal and written communication skills. 

CONTACT INFORMATION

HOW TO APPLY:

Please send or email CV and letters of recommendation directly to:

Dr. Bali Pulendran

Research Professor

Emory Vaccine Center at Yerkes

954 Gatewood Rd NE

Atlanta, Georgia 30329

bpulend@emory.edu 

NOTE: PLEASE DO NOT APPLY ONLINE FOR THIS POSITION. APPLY DIRECTLY TO THE DEPARTMENT USING THE INFORMATION PROVIDED ABOVE.