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ID#: PA-11-218     Posted: 31 May 2011
Mechanistic Studies of HIV-exposed Seronegative Individuals (HESN) (R01)
Deadline: 8 May 2014
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Type of Grant: Research
National Institutes of Health (NIH)

The National Institutes of Health (NIH), a part of the U.S. Department of Health and Human Services External Web Site Policy , is the nation’s medical research agency—making important discoveries that improve health and save lives.

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The purpose of this initiative is to support mechanistic studies of individuals who are repeatedly exposed to HIV but remain seronegative (HESN), or demonstrate resistance to infection.  Projects supported under this FOA could involve cellular, structural and systems biology; host and viral genetics; immunology, or virology.  All projects focusing on the phenomenon of HESNs are encouraged, including those involving mechanisms responsible for establishing and maintaining seronegativity or resistance to infection, new assay development, mathematical, cell, and animal model development, and development of new technologies needed for expansion of our understanding of HESNs.  Applicants are encouraged to show how proposed studies will explore the mechanisms underlying HIV seronegativity or resistance.


Any individual(s) with the skills, knowledge, and resources necessary to carry out the proposed research as the Program Director/Principal Investigator (PD/PI) is invited to work with his/her organization to develop an application for support. Individuals from underrepresented racial and ethnic groups as well as individuals with disabilities are always encouraged to apply for NIH support.
For institutions/organizations proposing multiple PDs/PIs, visit the Multiple Program Director/Principal Investigator Policy and submission details in the Senior/Key Person Profile (Expanded) Component of the SF 424 (R&R) Application Guide:


Ann Devine
Division of Extramural Activities
National Institute of Allergy and Infectious Diseases
Room 2114, MSC-7614
6700B Rockledge Drive
Bethesda, MD 20892-7614
Telephone: 301-402-5601
Fax: 301-480-3780