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Posted: 31 Oct 2011
The clarification and purification high-density PER.C6 cell cultures Internship-Leiden, The Netherlands
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Viral Diversity

Crucell is a global biopharmaceutical company dedicated to bringing meaningful innovation to global health. We do this by discovering, developing, manufacturing and marketing products that combat major threats to the health of people worldwide. Our specialty is fighting infectious diseases—a growing healthcare challenge.

Innovation is the drive force behind our strong research & development (R&D) pipeline, with promising products in pre-clinical and clinical development. Crucell product candidates include flu-mAb, and antibody product effective against a broad range of influenza virus strains, tuberculosis and malaria vaccines, as well as a rabies monoclonal antibody combination-all produced on our unique PER.C6® human-cell technology.

Currently we are combating twelve major infectious diseases with our range of marketed vaccines in the paediatric, travel & endemic and respiratory fields. 

The combination of our innovative technologies and creative minds drives Crucell’s success, which we measure in human and business terms. 

Johnson & Johnson completed the tender offer for Crucell N.V. (Crucell) on 22nd February 2011 and declared the offer unconditional. As a result, Crucell will now operate as the center for vaccines within the Johnson & Johnson pharmaceuticals group.

Headquartered in Leiden, the Netherlands, Crucell currently employs 1400 people and has offices in China, Indonesia, Italy, Korea, Malaysia, Spain, Sweden, Switzerland, the UK the USA and Vietnam.



The ‘Down Stream Processing’ (DSP) department develops processes for purifying and formulating (recombinant) viruses and antibodies from fermentation medium. These processes must be safe, economical and scalable. They will be implemented in a GMP production facility for the production of clinical batches and scaled-up for commercial production.

Job Description:
We are looking for a motivated student looking to gain experience working in industry. You will be involved in the analysis of samples from the development of clarification and purification processes for high-density PER.C6 feed streams with record high antibody or (recombinant) viruses titers. The techniques include titer (affinity HPLC) and aggregate analysis (HP-SEC analysis) on a state of the art analytical HPLC, impurity profiles on SDS-PAGE and host cell protein determination on ELISA.


Minimum Qualifications:

We are looking for an enthusiastic MLO student in a relevant discipline such as biochemistry, life sciences or related fields.

The most important competencies for this position are accuracy, enthusiasm and good planning and communication skills. In addition, you need to be eager to learn and able to work independently.


As part of Crucell's recruitment policy, a pre-employment screening will take place during the recruitment process.


For more information contact:

Human Resources, 071-5197481

To send an application, use the "Apply here" button above or send your short letter of motivation and CV to:

Human Resources
P.O. Box 2048
2301 CA Leiden