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Posted: 5 May 2011
30 years in 30 weeks: Table of Contents

To commemorate World AIDS Day (December 1) and the 30th anniversary of the discovery of AIDS, the Global HIV Vaccine Enterprise is taking a retrospective look at the last 30 years of HIV research through its new online series, “HIV/AIDS: 30 years in 30 weeks.” The series reviews some of the most influential scientific papers on HIV published from 1981 to 2011. Each week, for 30 weeks, one paper and an accompanying commentary by its author(s) will be published to review the motivation behind the paper and the impact of its findings on the field. 

Year Reference Paper Author
  Introduction   Alan Bernstein
1981 Pneumocystis carinii pneumonia and mucosal candidiasis in previously healthy homosexual men: Evidence of a new acquired cellular immunodeficiency
N Engl J Med. 1981 Dec 10;305(24):1425-31
Gottlieb, M., Schroff, R., Schanker, H., Weisman, J., Fan, P., Wolf, R., Saxon, A.
pdf Michael Gottlieb
1982 Opportunistic infection in previously healthy women. Initial manifestations of a community-acquired cellular immunodeficiency
Annals of internal medicine 1982 ;97(4): 533-9.
Masur H; Michelis M A; Wormser G P; Lewin S; Gold J; Tapper M L; Giron J; Lerner C W; Armstrong D; Setia U; Sender J A; Siebken R S; Nicholas P; Arlen Z; Maayan S; Ernst J A; Siegal F P; Cunningham-Rundles S
pdf Henry Masur
1983 Isolation of a T-lymphotropic retrovirus from a patient at risk for Acquired Immune Deficiency Syndrome (AIDS)
Science, Vol. 220, No. 4599. (May 20, 1983), pp. 868-871.
F. Barré-Sinoussi; J. C. Chermann; F. Rey; M. T. Nugeyre; S. Chamaret; J. Gruest; C. Dauguet; C. Axler-Blin; F. Vézinet-Brun; C. Rouzioux; W. Rozenbaum; L. Montagnier
Françoise Barré-Sinoussi
1984 Detection, isolation, and continuous production of cytopathic retroviruses (HTLV-III) from patients with AIDS and pre-AIDS
Science, 4 May 1984: Vol. 224 no. 4648 pp. 497-500
M Popovic, MG Sarngadharan, E Read and RC Gallo
pdf Robert Gallo
1985 Nucleotide sequence of the AIDS virus, LAV
Cell. 1985 Jan;40(1):9-17.
Wain-Hobson S, Sonigo P, Danos O, Cole S, Alizon M.

3'-Azido-3'-deoxythymidine (BW A509U): An antiviral agent that inhibits the infectivity and cytopathic effect of human T-lymphotropic virus type III/lymphadenopathy-associated virus in vitro
Proc. Nati. Acad. Sci. USA Vol. 82, pp. 7096-7100, October 1985
Hiroaki Mitsuya, Kent J.Weinhold, Phillip A. Furman,  Marty H. St. Clair, Sandra Nusinoff Lehrman, Robert  C. Gallo, Dani Bolognesi, David W. Barry, and Samuel Broder



Simon Wain-Hobson

Samuel Broder

1986 The T4 gene encodes the AIDS virus receptor and is expressed in the immune system and the brain
Cell. 1986 Nov 7;47(3):333-48.
Maddon PJ, Dalgleish AG, McDougal JS, Clapham PR, Weiss RA, Axel R.
pdf Robin Weiss
1987 The efficacy of azidothymidine (AZT) in the treatment of patients with AIDS and AIDS-related complex. A double-blind, placebo-controlled trial
N Engl J Med. 1987 Jul 23;317(4):185-91.
Fischl MA, Richman DD, Grieco MH, Gottlieb MS, Volberding PA, Laskin OL, Leedom JM, Groopman JE, Mildvan D, Schooley RT, et al.
pdf Margaret Fischl
1988 Cellular uptake of the Tat protein from human immunodeficiency virus
Cell, Vol. 55, 1189-l 193. December 23, 1988, Copyright 1988 by Cell Press
Alan Frankel and Carl Pabo
pdf Alan Frankel
1989 HIV with reduced sensitivity to zidovudine (AZT) isolated during prolonged therapy
Science 31 March 1989: Vol. 243 no. 4899 pp. 1731-1734
BA Larder, G Darby and DD Richman
pdf Doug Richman
1990 HIV-1 Entry into quiescent primary lymphocytes: Molecular analysis reveals a labile, latent viral structure
Cell, Vol. 61. 213-222, April 20, 1990, Copyright 0 1990 by Cell Press
Jerome A. Zack, Salvatore J. Arrigo, Stacy R. Weitsman, Alan S. Go, Allyson Haislip, and Irvin S. Y. Chen
pdf Jerome Zack and Irvin Chen
1991 A large array of human monoclonal antibodies to type 1 human immunodeficiency virus from combinatorial libraries of asymptomatic seropositive individuals
Proc Natl Acad Sci U S A. 1991 Nov 15;88(22):10134-7.
Burton DR, Barbas CF 3rd, Persson MA, Koenig S, Chanock RM, Lerner RA.

Human immunodeficiency virus genetic variation that can escape cytotoxic T cell recognition
Nature. 1991 Dec 12;354(6353):453-9.
Phillips RE, Rowland-Jones S, Nixon DF, Gotch FM, Edwards JP, Ogunlesi AO, Elvin JG, Rothbard JA, Bangham CR, Rizza CR, & Andrew J. McMichael





Dennis Burton


Andrew McMichael
1992 Protective effects of a live attenuated SIV vaccine with a deletion in the nef gene
Science vol. 258, 18 December 1992
Muthiah D. Daniel, Frank Kirchhoff, Susan C. Czajak, Prabhat K. Sehgal, Ronald C. Desrosiers
pdf Ronald Desrosiers
1993 HIV infection is active and progressive in lymphoid tissue during the clinically latent stage of disease
Nature, 362:355-358, 1993.
Pantaleo, G, C. Graziosi, JF Demarest, L Butini, M Montoni, CH Fox, JM Orenstein, DP Kotler and AS Fauci.
pdf Giuseppe Pantaleo and Anthony S. Fauci
1994 Temporal association of cellular immune responses with the initial control of viremia in primary human immunodeficiency virus type 1 syndrome
Koup RA, Safrit JT, Cao Y, Andrews CA, McLeod G, Borkowsky W, Farthing C, Ho DD.
J Virol. 1994 Jul;68(7):4650-5.
pdf Richard Koup
1995 Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection
Nature. 1995 Jan 12;373(6510):123-6.
Ho DD, Neumann AU, Perelson AS, Chen W, Leonard JM, Markowitz M.
pdf Martin Markowitz and David Ho
1996 In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector
Science. 1996 Apr 12;272(5259):263-7.
Naldini L, Blömer U, Gallay P, Ory D, Mulligan R, Gage FH, Verma IM, Trono D.
pdf Didier Trono
1997 Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therapy
Science. 1997 Nov 14;278(5341):1295-300.
Finzi D, Hermankova M, Pierson T, Carruth LM, Buck C, Chaisson RE, Quinn TC, Chadwick K, Margolick J, Brookmeyer R, Gallant J, Markowitz M, Ho DD, Richman DD, Siliciano RF.
pdf Diana Finzi and Robert Siliciano
1998 Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody
Nature. 1998 Jun 18;393(6686):648-59.
Kwong PD, Wyatt R, Robinson J, Sweet RW, Sodroski J, Hendrickson WA.
pdf Peter Kwong and Joseph Sodroski

Control of viremia in simian immunodeficiency virus infection by CD8+ lymphocytes
Science. 1999 Feb 5;283(5403):857-60.
Schmitz JE, Kuroda MJ, Santra S, Sasseville VG, Simon MA, Lifton MA, Racz P, Tenner-Racz K, Dalesandro M, Scallon BJ, Ghrayeb J, Forman MA, Montefiori DC, Rieber EP, Letvin NL, Reimann KA.

pdf Joern Schmitz
2000 DC-SIGN, a dendritic cell-specific HIV-1-binding protein that enhances trans-infection of T cells
Cell. 2000 Mar 3;100(5):587-97.
Geijtenbeek TB, Kwon DS, Torensma R, van Vliet SJ, van Duijnhoven GC, Middel J, Cornelissen IL, Nottet HS, KewalRamani VN, Littman DR, Figdor CG, van Kooyk Y.
pdf Teunis Geijtenbeek
2001 Control of a mucosal challenge and prevention of AIDS by a multiprotein DNA/MVA vaccine
Science. 2001 Apr 6;292(5514):69-74.
Amara RR, Villinger F, Altman JD, Lydy SL, O'Neil SP, Staprans SI, Montefiori DC, Xu Y, Herndon JG, Wyatt LS, Candido MA, Kozyr NL, Earl PL, Smith JM, Ma HL, Grimm BD, Hulsey ML, Miller J, McClure HM, McNicholl JM, Moss B, Robinson HL.
Harriet Robinson
2002  Isolation of a human gene that inhibits HIV-1 infection and is suppressed by the viral Vif protein
Nature. 2002 Aug 8;418(6898):646-50. Epub 2002 Jul 14.
Sheehy AM, Gaddis NC, Choi JD, Malim MH.
Michael Malim and Ann Sheehy
2003  The protein network of HIV budding
Cell. 2003 Sep 19;114(6):701-13.
von Schwedler UK, Stuchell M, Müller B, Ward DM, Chung HY, Morita E, Wang HE, Davis T, He GP, Cimbora DM, Scott A, Kräusslich HG, Kaplan J, Morham SG, Sundquist WI.

Wesley Sundquist
2004  The cytoplasmic body component TRIM5alpha restricts HIV-1 infection in Old World monkeys
Nature. 2004 Feb 26;427(6977):848-53.
Stremlau M, Owens CM, Perron MJ, Kiessling M, Autissier P, Sodroski J.

Joseph Sodroski and Matthew Stremlau
2005  Massive infection and loss of memory CD4+ T cells in multiple tissues during acute SIV infection
Nature. 2005 Apr 28;434(7037):1093-7.
Mattapalli JJ, Douek DC, Hill B, Nishimura Y, Martin M, Roederer M.

 Joseph Matapallil and Mario Roederer
2006  PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression
Nature. 2006 Sep 21;443(7109):350-4. Epub 2006 Aug 20.
Day CL, Kaufmann DE, Kiepiela P, Brown JA, Moodley ES, Reddy S, Mackey EW, Miller JD, Leslie AJ, DePierres C, Mncube Z, Duraiswamy J, Zhu B, Eichbaum Q, Altfeld M, Wherry EJ, Coovadia HM, Goulder PJ, Klenerman P, Ahmed R, Freeman GJ, Walker BD.

 Bruce Walker
2007  Male circumcision for HIV prevention in young men in Kisumu, Kenya: a randomised controlled trial
Lancet. 2007 Feb 24;369(9562):643-56.
Bailey RC, Moses S, Parker CB, Agot K, Maclean I, Krieger JN, Williams CF, Campbell RT, Ndinya-Achola JO.

Stephen Moses
2008  Efficacy assessment of a cell-mediated immunity HIV-1 vaccine (the Step Study): a double-blind, randomised, placebo-controlled, test-of-concept trial
Lancet. 2008 Nov 29;372(9653):1881-93. Epub 2008 Nov 13.
Buchbinder SP, Mehrotra DV, Duerr A, Fitzgerald DW, Mogg R, Li D, Gilbert PB, Lama JR, Marmor M, Del Rio C, McElrath MJ, Casimiro DR, Gottesdiener KM, Chodakewitz JA, Corey L, Robertson MN; Step Study Protocol Team.

Susan Buchbinder
2009 Vaccination with ALVAC and AIDSVAX to prevent HIV-1 infection in Thailand
N Engl J Med. 2009 Dec 3;361(23):2209-20.
Rerks-Ngarm S, Pitisuttithum P, Nitayaphan S, Kaewkungwal J, Chiu J, Paris R, Premsri N, Namwat C, de Souza M, Adams E, Benenson M, Gurunathan S, Tartaglia J, McNeil JG, Francis DP, Stablein D, Birx DL, Chunsuttiwat S, Khamboonruang C, Thongcharoen P, Robb ML, Michael NL, Kunasol P, Kim JH; MOPH-TAVEG Investigators.

Jerome Kim
2010 Effectiveness and safety of tenofovir gel, an antiretroviral microbicide, for the prevention of HIV infection in women
Science. 2010 Sep 3;329(5996):1168-74. Epub 2010 Jul 19.
Abdool Karim Q, Abdool Karim SS, Frohlich JA, Grobler AC, Baxter C, Mansoor LE, Kharsany AB, Sibeko S, Mlisana KP, Omar Z, Gengiah TN, Maarschalk S, Arulappan N, Mlotshwa M, Morris L, Taylor D; CAPRISA 004 Trial Group.

Quarraisha Abdool Karim and Salim Abdool Karim
Thirty years in review, and a look toward the future   Jose Esparza and Bonnie Mathieson