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Posted: 18 Aug 2011

At the 11th International Conference on AIDS in Vancouver in July of 1996, the results of the first trials of triple-combination therapy were announced, showing dramatic improvement in patients’ health. Combination therapy, also called HAART (highly active antiretroviral therapy) became the gold standard of treatment in the following years...

Posted: 11 Aug 2011

Two years before the publication of the paper featured this week, Pantaleo et al. (see 1993, this series) showed that HIV damages the lymphoid tissue of an infected person even before the onset of symptoms of AIDS. Ho et al. expanded on that finding by showing that in asymptomatic patients the virus is actively replicating, new cells are...

Posted: 4 Aug 2011

Many viral infections resolve and leave the individual immune to the repeated viral challenges. Such cases can serve as a guide and a model for vaccine development. However, HIV infection is chronic and no cases of the complete clearance of the virus are known. Nevertheless, the evidence for immune control of virus replication existed in...

Posted: 1 Aug 2011

The family of lentiviruses, to which HIV belongs, were named so because they cause slowly progressive diseases after long periods of incubation ((lenti-, Latin for "slow").  Initially, HIV was also believed to remain latent because of the long time that typically separated infection and onset of AIDS.  However, in an important...

Posted: 21 Jul 2011

Soon after the discovery of HIV, a whole family of related viruses were found to naturally infect a variety of African nonhuman primates. The simian immunodeficiency viruses (SIVs) became useful models for HIV. The SIV models allow study of viral transmission, pathogenesis and vaccine concepts under well-controlled laboratory conditions. In...