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Posted: 16 Jul 2011

Recognition of the challenges in the development of an HIV vaccine led to studies that aimed to characterize and understand human immune responses during natural infection, as well as viral ability to evade them. In their commentary, Drs. Burton, Barbas and Lerner describe one of the first large-scale approaches to isolate anti-HIV...

Posted: 7 Jul 2011

From the very first report of AIDS, which identified the deficiency of the CD4+ subset of T cells in patients, HIV research relied on the latest findings and technological advances in human immunology. The information flow, however, occurred in both directions, with HIV research uncovering many previously unknown facts about the immune...

Posted: 24 Jun 2011

Results of the second clinical trial of AZT were published in 1989, providing evidence that the drug not only benefited those who already had AIDS, but could also slow progression of the disease in people who were HIV-infected. The excitement caused by the results of that trial was overshadowed by the finding, made in the laboratory of Dr....

Posted: 22 Jun 2011

While public health experts were exploring strategies to prevent the spread of HIV and clinicians were attempting to develop drugs that might treat or perhaps even cure AIDS, laboratory scientists were studying the virus itself. From the first sequence of HIV, published in 1985 (see Wain-Hobson, this series), it was clear that the virus...

Posted: 27 May 2011

Important discoveries were made in 1987, including the confirmation that HIV can be transmitted through breast milk to infants from infected mothers. In addition,  specific regions of the envelope protein that mediate interactions with the CD4 receptor were identified. But undoubtedly one of the most important findings of that year...